Serum Procalcitonin Level for Prediction of High-grade Vesicoureteral Reflux in Urinary Tract Infection

Authors

  • Nahid Rahimzadeh Pediatric Transplantation and Dialysis Research Center, Tehran University of Medical Sciences, Tehran, Iran
  • Hasan Otukesh Pediatric Transplantation and Dialysis Research Center, Tehran University of Medical Sciences, Tehran, Iran
  • Rozita Hoseini Pediatric Transplantation and Dialysis Research Center, Tehran University of Medical Sciences, Tehran, Iran
  • Shiva Shadani Pediatric Transplantation and Dialysis Research Center, Tehran University of Medical Sciences, Tehran, Iran
  • Nakysa Hooman Pediatric Transplantation and Dialysis Research Center, Tehran University of Medical Sciences, Tehran, Iran

Abstract

Introduction. Procalcitonin is a reliable and specific marker of bacterial infections such as urinary tract infection. Some authors suggest measurement of serum procalcitonin as a predictor of vesicoureteral reflux (VUR). We investigated this association in children admitted because of acute pyelonephritis.

Materials and Methods. Forty-eight children with the first febrile urinary tract infection were included. Twelve patients had low-grade VUR, 9 patients had high-grade VUR, and 27 patients did not have any VUR in their imaging assessment.

Results. There was a significant association between high-grade VUR and higher levels of procalcitonin (P = .04). The sensitivity of a procalcitonin level of 0.31 ng/mL or greater was 90% and the specificity was 32% for diagnosis of high-grade VUR.

Conclusions. We concluded that serum procalcitonin concentration is a sensitive and promising predictor of high-grade VUR.

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Published

2014-03-20

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Section

ORIGINAL | Kidney Diseases