Arterial Atherosclerosis in Patients With Chronic Kidney Disease and Its Relationship With Serum and Tissue Endothelin-1

Authors

  • Hamid Noshad Division of Nephrology, Drugs Applied Research Center, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran Author
  • Hassan Argani Division of Nephrology, Department of Medicine, Shahid Beheshti University of Medical Sciences, Tabriz, Iran Author
  • Nariman Nezami Drugs Applied Research Center, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran Author
  • Morteza Ghojazadeh Drugs Applied Research Center, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran Author
  • Afshar Zomorrodi Department of Urology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran Author
  • Abolfazl Bohlouli Department of Urology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran Author
  • Mohammad Reza Bonyadi Drugs Applied Research Center, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran Author
  • Ashraf Fakhrjou Department of Pathology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran Author
  • Amir Ghorbanihaghjo Drugs Applied Research Center, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran Author
  • Abasat Gharedaghi Department of Surgery, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran Author
  • Hasan Javadzadegan Division of Cardiology, Department of Medicine, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran Author
  • Shahram Sadreddini Division of Rheumatology, Department of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran Author

Abstract

Instruction. We investigated the correlation between atherosclerosis and tissue and serum levels of endothelin-1 in patients with chronic kidney disease (CKD).

Materials and Methods. Arterial samples were obtained from 35 patients with CKD during arteriovenous fistula placement. Thirty-one patients with cardiovascular disease who underwent coronary artery bypass graft (CABG) were selected as the atherosclerotic group, and a piece of their aorta punched during CABG was obtained. Also, a small piece of the renal artery was dissected during donation in 24 kidney donors (control group). Tissue endothelin-1 level was measured and atherosclerosis grading was determined by pathologic examination. Serum levels of endothelin-1 were also measured in the three groups.

Results. The mean tissue endothelin-1 levels were 10.73±7.57 pg/mL, 12.16 ± 3.95 pg/mL, and 0.93 ± 1.06 pg/mL in the patients with CKD, those with CABG, and donors, respectively (P < .001). The mean serum endothelin-1 level was 25.23 ± 15.15 pg/mL in the patients with CKD, 21.13 ± 17.22 pg/mL in the patients with CABG, and 2.66 ± 1.51 pg/mL in the donors (P < .001). Atherosclerosis grades correlated with tissue endothelin-1 level (r = 0.823, P < .001) and serum endothelin-1 level (r = 0.608, P < .001) in the patients with CKD. Multiple regression analysis showed tissue endothelin-1 level as the main predicting factor of atherosclerosis (P < .001).

Conclusions. Tissue endothelin-1 concentration is more important than serum endothelin-1 or lipids levels in prediction of atherosclerosis. Thus, blockade of tissue endothelin-1 receptors with its antagonists may prevent atherosclerosis progression.

Downloads

Download data is not yet available.

Downloads

Published

2009-10-12

Issue

Section

ORIGINAL | Kidney Diseases

How to Cite

Arterial Atherosclerosis in Patients With Chronic Kidney Disease and Its Relationship With Serum and Tissue Endothelin-1. (2009). Iranian Journal of Kidney Diseases, 3(4), 203-209. https://www.ijkd.org/index.php/ijkd/article/view/107

Most read articles by the same author(s)

1 2 > >>