Immune Disorders in Hemodialysis Patients

Authors

  • Mohammad Reza Sharif Department of Pediatrics, Kashan University of Medical Sciences, Kashan, Iran Author
  • Zahra Chitsazian Department of Internal Medicine, Kashan University of Medical Sciences, Kashan, Iran Author
  • Mehdi Moosavian Department of Internal Medicine, Sabzevar University of Medical Sciences, Sabzevar, Iran Author
  • Fariba Raygan Department of Cardiology, Kashan University of Medical Sciences, Kashan, Iran Author
  • Hassan Nikoueinejad Department of Nephrology and Urology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran Author
  • Ali Reza Sharif Department of Infectious Diseases, Kashan University of Medical Sciences, Kashan, Iran Author
  • Behzad Einollahi Department of Nephrology and Urology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran Author

Abstract

Immunologically, End Stage renal Disease (ESRD) is associated with some disorders in both innate and adaptive immune system in such a form that there is a coexistence of both immune activation and immune suppression. Although these disorders are complex yet thoroughly unknown, there is a close relation between the progressively defective immune system with side effects as well as mortality causes including cardiovascular problems, infections, and malignancies. From the other point, chronic inflammation as a major determinant of "dialysis syndrome" (including malnutrition, cachexia, and vasculopathy) is considered as the main factor of inability and mortality in dialysis patients. Such inflammation is generally arisen from immune system response to uremia and individual's repetitive contact with dialysis instruments and, in the long term, leads to premature aging via intensifying tissue degeneration. Therefore, the immune system is known as one of the most important therapeutic targets to reduce morbidity and mortality in uremic and dialysis patients.   This review addresses different aspects as well as mechanisms of immune system dysfunction and possible therapeutics in dialysis patients.

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Author Biographies

  • Mohammad Reza Sharif, Department of Pediatrics, Kashan University of Medical Sciences, Kashan, Iran
  • Zahra Chitsazian, Department of Internal Medicine, Kashan University of Medical Sciences, Kashan, Iran
  • Mehdi Moosavian, Department of Internal Medicine, Sabzevar University of Medical Sciences, Sabzevar, Iran
  • Fariba Raygan, Department of Cardiology, Kashan University of Medical Sciences, Kashan, Iran
  • Hassan Nikoueinejad, Department of Nephrology and Urology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran
  • Ali Reza Sharif, Department of Infectious Diseases, Kashan University of Medical Sciences, Kashan, Iran
  • Behzad Einollahi, Department of Nephrology and Urology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran

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Published

2015-04-07

Issue

Section

REVIEW | Dialysis

How to Cite

Immune Disorders in Hemodialysis Patients. (2015). Iranian Journal of Kidney Diseases, 9(2), 84-96. https://www.ijkd.org/index.php/ijkd/article/view/1661

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