Soluble Major Histocompatibility Complex Class I Chain-related Antigen A Level in Chronic Allograft Dysfunction

Authors

  • Sara Assadiasl Department of Immunology, School of medicine, Tehran University of medical sciences, Tehran, Iran
  • Pedram Ahmadpoor Chronic Kidney Disease Research Center, Labbafinejad Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  • Mohsen Nafar Chronic Kidney Disease Research Center, Labbafinejad Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  • Mahboob Lesan Pezeshki Nephrology research center, Imam Khomeini hospital, Tehran University of medical sciences, Tehran, Iran
  • Peyman Mohammadi Torbati Dept. of Pathology, Labbafinejad hospital, Shahid Behshti University of medical sciences, Tehran, Iran
  • Mohammad Hosein Nicknam Molecular Immunology Research Center, Tehran University of medical sciences, Tehran, Iran
  • Aliakbar Amirzargar Department of Immunology, Medical school, Tehran University of medical sciences, Pour Sina Ave, Tehran, Iran

Abstract

Introduction. Soluble major histocompatibility complex class I chain-related antigen A (soluble MICA) has recently been considered as an inhibitory molecule which is shed from tumors and protects them against natural killers and some subgroups of T cells' cytolysis. In transplantation, soluble MICA is also a foreign antigenic molecule that can induce allospecific responses. This study aimed to clarify its possible role in long-term kidney allograft outcome.

Materials and Methods. Thirty patients with biopsy-proven chronic allograft dysfunction (CAD) were pair-matched with kidney allograft recipients with 30 stable graft function. Fifteen healthy individuals were enrolled as controls. Soluble MICA antigen and anti-HLA antibodies were measured in their serum.

Results. There was no significant difference between CAD patients, stable recipients, and healthy volunteers in frequency or titer of soluble MICA; however, soluble MICA-positive patients were more frequent in the stable group was than the CAD group (43.4% versus 33.3%). In addition, a high level of soluble MICA was accompanied by enhanced humoral responses. No significant difference was found in anti-HLA antibodies production between the CAD and stable groups.

Conclusions. Our data suggest that soluble MICA, at least in a defined range, can protect the allograft against natural killers and T cell cytolysis; nonetheless, its excessive amounts might stimulate immune system to exert enhanced humoral response. In order to confirm the protective or detrimental role of soluble MICA in kidney transplantation, conducting larger studies is necessary.

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Published

2015-04-07

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Section

ORIGINAL | Transplantation