A 4-year Follow-up of Living Unrelated Donors of Kidney Allograft in Iran

Authors

  • Ali Nobakht Haghighi Division of Nephrology, Department of Internal Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran Author
  • Tahereh Malakoutian Hasheminejad Clinical Research Development Center, Hasheminejad Kidney Center, Iran University of Medical Sciences, Tehran, Iran Author
  • Mohammadhadi Radfar Hasheminejad Clinical Research Development Center, Hasheminejad Kidney Center, Iran University of Medical Sciences, Tehran, Iran Author
  • Ezatollah Abdi Hasheminejad Clinical Research Development Center, Hasheminejad Kidney Center, Iran University of Medical Sciences, Tehran, Iran Author
  • Mohammad Kamgar Long Beach Memorial Medical Center, Long Beach, California, USA Author
  • Behrooz Broumand Division of Nephrology, Department of Internal Medicine, Iran University of Medical Sciences, Tehran, Iran Author
  • Iradj Fazel Department of Surgery, Shahid Beheshti University of Medical Sciences, Tehran, Iran Author

Abstract

Introduction. Shortage of deceased donor kidneys has resulted in an increased rate of kidney transplantation from living unrelated donors (LURDs). However, there are concerns about short-term and long-term morbidity of the donors. This study reports the clinical and biochemical factors in a follow-up program of Iranian LURDs, one of the largest reported series of kidney donors.

Materials and Methods. Of 7500 individuals who underwent living donor nephrectomies between 2005 and 2008, a total of 1549 participated in this study. They were followed for 18 to 48 months after the kidney donation. The average time for the first study visit was 316.72 days after donation.

Results. The mean age of donors was 30.43 ± 6.16 years old. Men consisted 82.5% of the group. Systolic hypertension was detected in 0.2% and diastolic hypertension in 1% of the LURDs; however, anemia prevalence was as high as 47.2%. Hyperuricemia was found in 21.2% of the LURDs, while proteinuria was seen in 13.7%. Glomerular filtration rate was greater than 90 mL/min in 38.2% of the donors, 60 mL/min to 90 mL/min in 54.5%, and less than 60 mL/min in 7.3%. A GFR less than 45 mL/min was seen in 0.1% of the donors.

Conclusions. Data suggested that the LURDs in Iran have an appropriate health condition comparable to other donors in other parts of the world. Considering the high prevalence of hyperuricemia in our population and its importance as a risk factor for kidney failure, monitoring serum uric acid in follow-up programs is suggested.

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Author Biographies

  • Ali Nobakht Haghighi, Division of Nephrology, Department of Internal Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
    Professor of Nephrology
  • Tahereh Malakoutian, Hasheminejad Clinical Research Development Center, Hasheminejad Kidney Center, Iran University of Medical Sciences, Tehran, Iran
    Department of NephrologyAssociate Professor of Nephrology
  • Mohammadhadi Radfar, Hasheminejad Clinical Research Development Center, Hasheminejad Kidney Center, Iran University of Medical Sciences, Tehran, Iran
    Associate Professor of urology
  • Ezatollah Abdi, Hasheminejad Clinical Research Development Center, Hasheminejad Kidney Center, Iran University of Medical Sciences, Tehran, Iran
    Associate Professor of Nephrology
  • Mohammad Kamgar, Long Beach Memorial Medical Center, Long Beach, California, USA
    Associate Professor of Nephrology
  • Behrooz Broumand, Division of Nephrology, Department of Internal Medicine, Iran University of Medical Sciences, Tehran, Iran
    Professor of Nephrology
  • Iradj Fazel, Department of Surgery, Shahid Beheshti University of Medical Sciences, Tehran, Iran
     Professor of surgery

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Published

2015-07-09

Issue

Section

SPECIAL REPORT | Transplantation

How to Cite

A 4-year Follow-up of Living Unrelated Donors of Kidney Allograft in Iran. (2015). Iranian Journal of Kidney Diseases, 9(4), 273-278. https://www.ijkd.org/index.php/ijkd/article/view/1904

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