Seroprevalence of Herpes Simplex Virus-2 in Kidney Transplant Recipients: A Single-Center Experience

Authors

  • Zakieh Rostamzadeh Khameneh Department of Microbiology, Urmia University of Medical Sciences, Urmia, Iran
  • Nariman Sepehrvand Student Research Committee, Urmia University of Medical Sciences, Urmia, Iran
  • Ali Taghizadeh-Afshari Department of Urology, Nephro-Urology Research Center, Urmia University of Medical Sciences, Urmia, Iran
  • Morteza Motazakker Department of Microbiology, Urmia University of Medical Sciences, Urmia, Iran
  • Ali Ghafari Department of Nephrology, Nephro-Urology Research Center, Urmia University of Medical Sciences, Urmia, Iran
  • Sima Masudi Department of Epidemiology, Urmia University of Medical Sciences, Urmia, Iran

Abstract

Introduction. Viral infections are a real threat in kidney transplant recipients because of their immunocompromised condition. This study aimed to evaluate herpes simplex virus-2 (HSV-2) seropositivity among kidney transplant recipients.

Materials and Methods. Serum samples of 91 kidney transplant recipients from Urmia, Iran, were examined serologically for antibodies against HSV-2 using an enzyme-linked immunosorbent assay.

Results. The mean time from transplantation at HSV-2 testing was 5.04 ± 4.45 years. The anti-HSV-2 immunoglobulin G antibody was positive in 5.4% of the kidney transplant recipients. Seropositive patients did not present any clinical manifestations of genital herpes infection. There was no association between HSV-2 seropositivity and age, gender, history of hemodialysis and transplantation, blood transfusion, or immunosuppressive regimen.

Conclusions. Seroprevalence of HSV-2 is not high among our kidney transplant recipients. However, it remains a source of concern, considering the compromised immune system in this specific population.

Author Biographies

  • Zakieh Rostamzadeh Khameneh, Department of Microbiology, Urmia University of Medical Sciences, Urmia, Iran
    Assisstant professor in Microbiology, Department of Microbiology, School of ParaMedicine, Urmia University of Medical Sciences
  • Nariman Sepehrvand, Student Research Committee, Urmia University of Medical Sciences, Urmia, Iran
    Student of Medicine, Student Research Center, Urmia University of Medical Sciences
  • Ali Taghizadeh-Afshari, Department of Urology, Nephro-Urology Research Center, Urmia University of Medical Sciences, Urmia, Iran
    Professor in Urology, Department of Urology, Urmia University of Medical Sciences.
  • Morteza Motazakker, Department of Microbiology, Urmia University of Medical Sciences, Urmia, Iran

    PhD in Virology, Assistant Professor, Department of Microbiology, also Head of the Deputy for Research Affairs, Urmia University of Medical Sciences

  • Ali Ghafari, Department of Nephrology, Nephro-Urology Research Center, Urmia University of Medical Sciences, Urmia, Iran

    Assistant Professor in Nephrology, Member of UroNephrology Research Center, Department of Nephrology, Urmia University of Medical Sciences

  • Sima Masudi, Department of Epidemiology, Urmia University of Medical Sciences, Urmia, Iran

    Master of Epidemiology, School of Public Health, also Secretary of the Devision for International Relations, Urmia University of Medical Sciences

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Published

2010-04-19

Issue

Section

ORIGINAL | Transplantation