Genetics and Epigenetics of Chronic Allograft Dysfunction in Kidney Transplants

Authors

  • Sepideh Zununi Vahed School of Advanced Biomedical Sciences; Research Center for Pharmaceutical Nanotechnology; Drug Applied Research Center; Tabriz University of Medical Sciences, Tabriz, Iran Author
  • Nasser Samadi School of Advanced Biomedical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran Author
  • Elmira Mostafidi Department of Pathology, Imam Reza Hospital, Tabriz University of Medical Sciences, Tabriz, Iran Author
  • Mohammad Reza Ardalan Kidney Research Center, Tabriz University of Medical Sciences, Tabriz, Iran Author
  • Yadollah Omidi Research Center for Pharmaceutical Nanotechnology, Tabriz University of Medical Sciences, Tabriz, Iran Author

Abstract

Chronic allograft dysfunction is the most common cause of allograft lost. Chronic allograft dysfunction happens as a result of complex interactions at the molecular and cellular levels. Genetic and environmental factors both influence the evolution and progression of the chronic allograft dysfunction. Epigenetic modification could be considered as a therapeutically modifiable element to pause the fibrosis process through novel strategies. In this review, the PubMed database was searched for English-language articles on these new areas.

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Author Biography

  • Mohammad Reza Ardalan, Kidney Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

    professor of medicin and nephrology

    kidney research center

    Tabriz University of Medical Sciences

    Tabriz-Iran

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Published

2016-01-29

Issue

Section

REVIEW | Transplantation

How to Cite

Genetics and Epigenetics of Chronic Allograft Dysfunction in Kidney Transplants. (2016). Iranian Journal of Kidney Diseases, 10(1), 1-9. https://www.ijkd.org/index.php/ijkd/article/view/2151

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