Absolute and Relative Carnitine Deficiency in Patients on Hemodialysis and Peritoneal Dialysis

Authors

  • Mitra Naseri Department of Pediatric Nephrology, Dr Sheikh Children Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
  • Hasan Mottaghi Moghadam Shahri Department of Pediatric Cardiology, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
  • Mohsen Horri Department of Pediatric Cardiology, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
  • Mohammad Esmaeeli Department of Pediatric Nephrology, Dr Sheikh Children Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
  • Fatemeh Ghaneh Sherbaf Department of Pediatric Nephrology, Dr Sheikh Children Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
  • Shohre Jahanshahi Hemodialysis Unit, Dr Sheikh Children Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
  • Giti Moeenolroayaa Hemodialysis Unit, Dr Sheikh Children Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
  • Zahra Rasoli Hemodialysis Unit, Dr Sheikh Children Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
  • Farzaneh Salemian Peritoneal Dialysis Unit, Dr Sheikh Children Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
  • Maryam Pour Hasan Hemodialysis Unit, Dr Sheikh Children Hospital, Mashhad University of Medical Sciences, Mashhad, Iran

Abstract

Introduction. Carnitine deficiency is commonly seen in dialysis patients. This study assessed the association dialysis and pediatric patients' characteristics with plasma carnitines levels.

Materials and Methods. Plasma carnitine concentrations were measured by tandem mass spectrometry in 46 children on hemodialysis or peritoneal dialysis. The total carnitine, free carnitine (FC), and L-acyl carnitine (AC) levels of 40 µmol/L and less, less than 7 µmol/L, and less than 15 µmol/L were defined low, respectively. An FC less than 20 µmol/L and an AC/FC ratio greater than 0.4 were considered as absolute and relative carnitine deficiencies. The correlation between carnitines levels and AC/FC ratio and age, duration of dialysis, characteristics of dialysis, and blood urea nitrogen and serum albumin concentrations were assessed.

Results. Absolute carnitine deficiency, low total carnitine, and low AC concentrations were found in 66.7%, 82.6%, and 51% of the patients, respectively. All of the patients had relative carnitine deficiency. Carnitine measurements were not significantly different between the hemodialysis and peritoneal dialysis groups. More severe relative carnitine deficiency was found in those with lower blood urea nitrogen levels and those on peritoneal dialysis. No linear correlation was found between carnitine levels and age, duration of dialysis, characteristics of dialysis, serum albumin level, or blood urea nitrogen level.

Conclusions. Absolute and relative carnitine deficiencies are common among children on dialysis. Patients with lower blood urea nitrogen levels and peritoneal dialysis patients are more prone to severe relative carnitine deficiency.

Author Biography

  • Mitra Naseri, Department of Pediatric Nephrology, Dr Sheikh Children Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
    Mashhad university of medicl sciences ,pediatric nephrology deprtment

Downloads

Published

2016-01-29

Issue

Section

ORIGINAL | Dialysis