Efficacy of Combined Plasmapheresis and Intravenous Immunoglobulin Therapy in Kidney Transplant Patients With Chronic Antibody-mediated Rejection

Authors

  • Ebru Gok Oguz Department of Nephrology, Diskapi Yildirim Beyazit Education and Research Hospital, Ankara, Turkey Author
  • Gulay Ulusal Okyay Department of Nephrology, Diskapi Yildirim Beyazit Education and Research Hospital, Ankara, Turkey Author
  • Hadim Akoglu Department of Nephrology, Diskapi Yildirim Beyazit Education and Research Hospital, Ankara, Turkey Author
  • Ozgur Merhametsiz Department of Nephrology, Diskapi Yildirim Beyazit Education and Research Hospital, Ankara, Turkey Author
  • Tolga Yildirim Department of Nephrology, Diskapi Yildirim Beyazit Education and Research Hospital, Ankara, Turkey Author
  • Basol Canbakan Department of Nephrology, Diskapi Yildirim Beyazit Education and Research Hospital, Ankara, Turkey Author
  • Mehmet Deniz Ayli Department of Nephrology, Diskapi Yildirim Beyazit Education and Research Hospital, Ankara, Turkey Author

Abstract

Introduction. Antibody-mediated rejections (AMRs) are critical clinical issues encountered in short- and long-term follow-up of kidney transplant patients. Whereas plasmapheresis is a mainstay treatment option in acute AMR cases, there is a paucity of data regarding its efficacy in management of chronic AMR. This report describes our experience addressing this issue.

Materials And Methods. We retrospectively investigated the data of 7 kidney transplant patients diagnosed with chronic AMR who were on 5 sessions of plasmapheresis (1 to 2 volume exchanges with fresh frozen plasma) on alternate days and 200 mg/kg of intravenous immunoglobulin after each session of plasmapheresis.

Results. At 6 months after the initiation of treatment, 6 patients experienced partially improved kidney function. One patient had no response and her kidney function progressively deteriorated.

Conclusions. Our preliminary results are encouraging for the combination of plasmapheresis and intravenous immunoglobulin as an adjunctive therapy for kidney transplant patients suffering from chronic AMR.  

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Author Biographies

  • Ebru Gok Oguz, Department of Nephrology, Diskapi Yildirim Beyazit Education and Research Hospital, Ankara, Turkey
    Nephrology Department
  • Gulay Ulusal Okyay, Department of Nephrology, Diskapi Yildirim Beyazit Education and Research Hospital, Ankara, Turkey
    Nephrology Department
  • Hadim Akoglu, Department of Nephrology, Diskapi Yildirim Beyazit Education and Research Hospital, Ankara, Turkey

    Nephrology Department

  • Ozgur Merhametsiz, Department of Nephrology, Diskapi Yildirim Beyazit Education and Research Hospital, Ankara, Turkey
    Nephrology Department
  • Tolga Yildirim, Department of Nephrology, Diskapi Yildirim Beyazit Education and Research Hospital, Ankara, Turkey
    Nephrology Department
  • Basol Canbakan, Department of Nephrology, Diskapi Yildirim Beyazit Education and Research Hospital, Ankara, Turkey
    Nephrology Department
  • Mehmet Deniz Ayli, Department of Nephrology, Diskapi Yildirim Beyazit Education and Research Hospital, Ankara, Turkey
    Nephrology Department

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Published

2016-05-18

Issue

Section

ORIGINAL | Transplantation

How to Cite

Efficacy of Combined Plasmapheresis and Intravenous Immunoglobulin Therapy in Kidney Transplant Patients With Chronic Antibody-mediated Rejection. (2016). Iranian Journal of Kidney Diseases, 10(3), 151-155. https://www.ijkd.org/index.php/ijkd/article/view/2413

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