Prevention of Contrast-induced Nephropathy With Oxygen Supplementation: a Randomized Controlled Trial

Authors

  • Farzanehsadat Minoo Nephrology Research Center; Center of Excellence in Nephrology, Tehran University of Medical Sciences, Tehran, Iran Author
  • Mahboob Lessan-Pezeshki Nephrology Research Center; Center of Excellence in Nephrology, Tehran University of Medical Sciences, Tehran, Iran Author
  • Ata Firouzi Cardiovascular Intervention Research Center, Rajaie Cardiovascular, Medical, and Research Center, Iran University of Medical Sciences, Tehran, Iran Author
  • Salman Nikfarjam School of Medicine, Guilan University of Medical Sciences, Rasht, Iran Author
  • Seyed Mansoor Gatmiri Nephrology Research Center; Center of Excellence in Nephrology, Tehran University of Medical Sciences, Tehran, Iran Author
  • Elham Ramezanzade Organ Transplantation Research Center, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran Author

Abstract

Introduction. The aim of the study was to investigate the efficacy of nasal oxygen as a supplementation to hydration therapy in reducing the risk of developing contrast-induced nephropathy (CIN).

Materials and Methods. In a randomized controlled trial, 348 patients scheduled to undergo elective coronary angiography were randomly allocated to standard hydration plus 2 L/min to 3 L/min nasal oxygen (from 10 minutes before the procedure until the end of the procedure) (n = 176) or standard hydration alone (n = 176). The primary outcome measure was development of CIN defined as either an increase of 25% or more in serum creatinine concentrations or an increment of at least 0.5 mg/dL in serum creatinine concentrations 48 hours after catheterization.

Results. Of the 348 patients who completed the study, 105 developed CIN (30.2%; 95% confidence interval, 25.4% to 35.0%). A diagnosis of CIN was made in 32 (18.6%) and 73 (41.5%) patients in the nasal oxygen and control arms, respectively (P < .001). In the intervention arm, creatinine concentrations postcontrast remained relatively constant (average change, 2.7%), whereas a significant increase of 17.3% was recorded in the control arm (P < .001; effect size, 11.8%).

Conclusions. Supplementation with nasal oxygen in addition to standard hydration appears to be an effective strategy in reducing CIN. The effect size for this intervention seems to be moderate.

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Published

2016-10-03

Issue

Section

ORIGINAL | Kidney Diseases

How to Cite

Prevention of Contrast-induced Nephropathy With Oxygen Supplementation: a Randomized Controlled Trial. (2016). Iranian Journal of Kidney Diseases, 10(5), 291-298. https://www.ijkd.org/index.php/ijkd/article/view/2671

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