Relationship of Serum Klotho Level With ACE Gene Polymorphism in Stable Kidney Allograft Recipients

Authors

  • Maryam Zaare Nahandi Chronic Kidney Disease Research Center, Sina Educational Hospital, Tabriz University of Medical Sciences, Tabriz, Iran Author
  • Mohamad Reza Ardalan Chronic Kidney Disease Research Center, Sina Educational Hospital, Tabriz University of Medical Sciences, Tabriz, Iran Author
  • Ali Banagozar Mohamadi Medical Philosophy and History Research Center, Department of Toxicology, Sina Educational Hospital, Tabriz University of Medical Sciences, Tabriz, Iran Author
  • Amir Ghorbani Haghjo Tabriz University of Medical Sciences, Tabriz, Iran Author
  • Morteza Jabbarpor Bonyadi Center of Excellence for Biodiversity, School of Natural Sciences, Tabriz University, Tabriz, Iran Author
  • Tahere Mohamadian Center of Excellence for Biodiversity, School of Natural Sciences, Tabriz University, Tabriz, Iran Author

Abstract

Introduction. The kidney is the main source of serum Klotho production. Immunosuppressive agents could affect the kidney in this regard. The effect of the ACE gene polymorphism on Klotho production is a less studied area. This study aimed to assess serum Klotho and ACE gene in a group of stable kidney transplant recipients.

Materials and Methods. In a cross-sectional study, 30 kidney transplant recipients with stable allograft function and 27 healthy young individuals were assessed for their serum Klotho levels. The ACE gene polymorphisms were studied in both groups.

Results. Klotho level was higher in kidney transplant recipients than the controls, but the difference was not significant (2.76 ± 2.41 ng/mL versus 2.01 ± 1.41 ng/mL, respectively). In both groups, serum Klotho level was higher in those with the I>I polymorphism, the men, those with higher glomerular filtration rate, and younger individuals, but the differences did not reach a significant level. Higher body mass index was significantly associated with lower serum Klotho level in both groups.

Conclusions. Klotho level after kidney transplantation meets the range in healthy individuals, and it is not affected by the ACE gene polymorphism.

Downloads

Download data is not yet available.

Author Biography

Downloads

Published

2017-02-07

Issue

Section

ORIGINAL | Transplantation

How to Cite

Relationship of Serum Klotho Level With ACE Gene Polymorphism in Stable Kidney Allograft Recipients. (2017). Iranian Journal of Kidney Diseases, 11(2), 151-156. https://www.ijkd.org/index.php/ijkd/article/view/2810