Vitamin D Receptor Gene Polymorphisms and Environment Influencing the Impact on Survival in Hemodialysis Patients

Authors

  • Cleber Machado-Souza School of Life Sciences, Pontifícia Universidade Católica do Paraná, Curitiba, Brazil Author
  • Ana Paula Ribeiro Braosi School of Medicine, Pontifícia Universidade Católica do Paraná, Curitiba, Brazil Author
  • Sônia Mara Luczyszyn School of Life Sciences, Pontifícia Universidade Católica do Paraná, Curitiba, Brazil Author
  • Marcia Olandoski School of Medicine, Pontifícia Universidade Católica do Paraná, Curitiba, Brazil Author
  • Miguel Carlos Riella Fundação PRO-RENAL, Curitiba, Brazil Author
  • Paula Cristina Trevilatto School of Life Sciences, Pontifícia Universidade Católica do Paraná, Curitiba, Brazil Author
  • Roberto Pecoits-Filho School of Medicine, Pontifícia Universidade Católica do Paraná, Curitiba, Brazil Author

Abstract

Introduction. The vitamin D-receptor axis is involved in multiple physiological functions and altered states such as hypertension, mineral metabolism disorders, and inflammation. These disturbances are major risk factors for progression to end-stage kidney disease and cardiovascular disease. In addition, changes in internal systemic environment could be influencing the impact of survival in patients with kidney disease. This study aimed to evaluate the impact of vitamin D receptor (VDR) polymorphisms on hemodialysis patients' survival.

Material and Methods. A total of 122 hemodialysis patients and 120 healthy controls were compared for VDR gene polymorphism. Markers for full coverage in the VDR gene were selected and genotyped. The hemodialysis patients were followed until death event, which was considered the primary endpoint for the survival analysis.

Results. Two tag SNPs (rs10875695 and rs11168293) showed significant differences between the hemodialysis and healthy patients. In survival analysis, the CC genotype for rs2248098, compared to the TT genotype, was associated with a worse mortality rate. After adjustments for age, sex, diabetes mellitus, and cardiovascular disease, the genotype CC (rs2248098) was associated with a higher risk of mortality in a multivariable analysis.

Conclusions. Polymorphisms specific to patients with kidney disease could be influencing different conditions associated with mortality. Thus, these genetic markers, rs2248098 for example, would act in a specific time in the history of kidney disease and would bring different results of patient survival outcomes.

Downloads

Download data is not yet available.

Author Biographies

  • Cleber Machado-Souza, School of Life Sciences, Pontifícia Universidade Católica do Paraná, Curitiba, Brazil
    School of Life Science
  • Ana Paula Ribeiro Braosi, School of Medicine, Pontifícia Universidade Católica do Paraná, Curitiba, Brazil
    School of Medicine
  • Sônia Mara Luczyszyn, School of Life Sciences, Pontifícia Universidade Católica do Paraná, Curitiba, Brazil
    School of Life Science
  • Marcia Olandoski, School of Medicine, Pontifícia Universidade Católica do Paraná, Curitiba, Brazil
    School of Medicine
  • Paula Cristina Trevilatto, School of Life Sciences, Pontifícia Universidade Católica do Paraná, Curitiba, Brazil
    School of Life Science
  • Roberto Pecoits-Filho, School of Medicine, Pontifícia Universidade Católica do Paraná, Curitiba, Brazil
    School of Medicine

Downloads

Published

2018-07-22

Issue

Section

ORIGINAL | Dialysis

How to Cite

Vitamin D Receptor Gene Polymorphisms and Environment Influencing the Impact on Survival in Hemodialysis Patients. (2018). Iranian Journal of Kidney Diseases, 12(4), 223-231. https://www.ijkd.org/index.php/ijkd/article/view/3769