Serum Apelin Peptide Level in Hemodialysis Patients With Pulmonary Arterial Hypertension

Authors

  • Mitra Samareh Fekri Department of Pulmonology, Cardiovascular Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran
  • Abbas Etminan Department of Nephrology, Clinical Research Unit, Shafa hospital, Kerman University of Medical Sciences, Kerman, Iran
  • Alireza Rashidnedjad Department of Cardiology, Shafa Hospital, Kerman University of Medical Sciences, Kerman, Iran
  • Aboozar Mojibian Department of Internal Medicine, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran
  • Yaser Masoomi Physiology Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran

Abstract

Introduction. Pulmonary arterial hypertension (PAH) is a destructive disease that is characterized by vasoconstriction, alterations and abnormal angiogenesis in pulmonary vessels, and right ventricular dysfunction. There is no certain treatment known for this condition. Patients with PAH have a lower level of apelin in their blood and less apelin is secreted in their endothelial cells, but this condition is not investigated in hemodialysis patients. This study aimed to compare apelin level in hemodialysis patients with and without PAH.

Materials and Methods. Forty hemodialysis patients with PAH were compared with 40 patients without the condition. Apelin serum level was measured using an enzyme-linked immunosorbent assay technique. Dialysis adequacy was measured and its relationship with apelin level and the pulmonary arterial pressure was investigated.

Results. The mean level of apelin in the group suffering from PAH was 54.87 ± 23.50 ng/L, while it was 76.85 ± 34.66 ng/L in those without PAH (P = .001). It was also found that hemodialysis adequacy had no effect on apelin level or pulmonary arterial pressure.

Conclusion. The findings of our study suggest that in hemodialysis patients with PAH, apelin peptide serum levels are significantly lower than patients with normal arterial pressure and this condition is not affected by hemodialysis.

Author Biographies

  • Mitra Samareh Fekri, Department of Pulmonology, Cardiovascular Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran
    Associate Professor of Pulmonology,  Cardiovascular Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences,   Kerman,  Iran.  
  • Abbas Etminan, Department of Nephrology, Clinical Research Unit, Shafa hospital, Kerman University of Medical Sciences, Kerman, Iran
    Assistant Professor of nephrology, Clinical Research Unit, Shafa hospital, Kerman University of Medical Sciences, Kerman, Iran.
  • Alireza Rashidnedjad, Department of Cardiology, Shafa Hospital, Kerman University of Medical Sciences, Kerman, Iran
    Assistant Professor of cardiology, Department of cardiology, Shafa hospital, Kerman University of Medical Sciences, Kerman, Iran.
  • Aboozar Mojibian, Department of Internal Medicine, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran
    Internist, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences,   Kerman,  Iran.
  • Yaser Masoomi, Physiology Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran
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Published

2018-07-11

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ORIGINAL | Kidney Diseases