The effect of curcumin in prevention of contrast nephropathy following coronary angiography or angioplasty in CKD patients

Authors

  • Maryam Hami
  • amir bigdeli
  • ramin khameneh bagheri
  • omid rajabi
  • maryam salehi
  • farnaz zahedi avval

Abstract

Introduction:

 Contrast-induced nephropathy (CIN) is the most common cause of iatrogenic acute kidney injury. It is happened more commonly in patients with underlying kidney diseases. It is appeared that the oxidative stress is the main mechanism of contrast nephropathy. Curcumin is suggested as an herbal antioxidant agent, so we decided to assess the effect of curcumin in preventing of this complication in patients with underlying chronic kidney disease (CKD) who need coronary angiography.

Methods & Materials:

We conducted double blind, placebo-controlled clinical trial in 60 moderate to severe CKD patients who underwent coronary angiography or angioplasty. Adjusted dose of Iodixanol was used as contrast agent in all of them. Curcumin or placebo administered orally, 1.5 g daily from 2 days before procedure to 3 days after it. CIN was defined by an increased serum creatinine level≥0.3mg/dl or an increase to ≥1.5 times of the baseline within 48 hours after procedure. Urinary NGAL test was also done the next day after angiography.

Results:

CIN occurred in 12(20%) of patients, 5(16.7%) in Curcumin group and 7(23.3%) in placebo group (odds ratio [OR], 0.56; 95% confidence interval [CI], 0.18 to 2.36; P0.51). Serum Creatinine was increased after72 hours of intervention from 1.65±0.26 mg/dl to 1.79±0.33 mg/dl in Curcumin group and from 1.61±0.23 mg/dl to 1.86±0.35 in placebo group. There is no significant difference between the mean increase in serum creatinine concentration in the placebo group and Curcumin group (difference of 0.006 mg/dL; 95% CI, - 0.06 to 0.08; P0.85). Urinary NGAL test was significantly higher in patients with AKI (p=0.000), but there weren’t differences in its level in two groups (p=0.761)

 Conclusion:

It is appeared prophylactic oral Curcumin hasn’t protective effects on CIN in high risk patients who have undergone coronary procedure.

Author Biographies

  • Maryam Hami

    Associate Professor of Nephrology, Kidney Transplantation Complications Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

     

  • amir bigdeli

    Assistant Professor of Nephrology, School of Medicine, Bojnourd University of Medical Sciences, Bojnourd, Iran

  • ramin khameneh bagheri

    Assistant Professor of Cardiology, Ghaem Hospital , School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

  • omid rajabi

    Associate Professor of Pharmaceutical Control, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran

     

  • maryam salehi

    Associate Professor of Community Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

  • farnaz zahedi avval

    Assistant Professor of Biochemistry, Ghaem Hospital , School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

     

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Published

2019-10-08

Issue

Section

ORIGINAL | Kidney Diseases