The Role of Dietary Antioxidants on Oxidative Stress in Diabetic Nephropathy

Authors

  • Francisco Gerardo Yanowsky-Escatell Nephrology Service, Civil Hospital of Guadalajara Dr. Juan I. Menchaca, Guadalajara, Jalisco, Mexico Author
  • Jorge Andrade-Sierra Department of Physiology, University Health Sciences Center (Centro Universitario de Ciencias de la Salud), University of Guadalajara. Guadalajara, Jalisco, Mexico Author
  • Leonardo Pazarín-Villaseñor Nephrology Service, Civil Hospital of Guadalajara Dr. Juan I. Menchaca, Guadalajara, Jalisco, Mexico Author
  • Christian Santana-Arciniega Surgery and Clinical Nutrition Service, Civil Hospital of Guadalajara Dr. Juan I. Menchaca, Guadalajara, Jalisco, Mexico Author
  • Eduardo de Jesús Torres-Vázquez Nephrology Service, Civil Hospital of Guadalajara Fray Antonio Alcalde, University Health Sciences Center (Centro Universitario de Ciencias de la Salud), University of Guadalajara, Guadalajara, Jalisco, Mexico Author
  • Jonathan Samuel Chávez-Iñiguez Nephrology Service, Civil Hospital of Guadalajara Fray Antonio Alcalde, University Health Sciences Center (Centro Universitario de Ciencias de la Salud), University of Guadalajara, Guadalajara, Jalisco, Mexico Author
  • Miguel Ángel Zambrano-Velarde Nephrology Service, Civil Hospital of Guadalajara Dr. Juan I. Menchaca, Guadalajara, Jalisco, Mexico Author
  • Francisco Martín Preciado-Figueroa Nephrology Service, Civil Hospital of Guadalajara Dr. Juan I. Menchaca, Guadalajara, Jalisco, Mexico Author

Abstract

Diabetic nephropathy (ND) is the leading cause of end-stage renal disease and oxidative stress (OS) has been recognized as a key factor in the pathogenesis and progression. Hyperglycemia, reactive oxygen species, advanced glycation end products, arterial pressure, insulin resistance, decrease in nitric oxide, inflammatory markers, and cytokines, among others; are involved in the presence of OS on ND. This revision focus on diverse studies in experimental and human models with diabetes and DN that has been demonstrated beneficial effects of different dietary antioxidant as resveratrol, curcumin, selenium, soy, catechins, α-lipoic acid, coenzyme Q10, omega-3 fatty acids, zinc, vitamins E and C, on OS and the capacity for antioxidant response. Therefore, this interventions could have a positive clinical impact on DN.

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Published

2020-03-05

Issue

Section

REVIEW | Kidney Diseases

How to Cite

The Role of Dietary Antioxidants on Oxidative Stress in Diabetic Nephropathy. (2020). Iranian Journal of Kidney Diseases, 14(2), 81-94. https://www.ijkd.org/index.php/ijkd/article/view/4984