Comparison Between eGFR by Schwartz Formula with Measured GFR by Radionuclide Diethylenetriamine Pentaacetic Acid Scan (Tc99 DTPA scan), in Patients Undergoing Chemotherapy with Nephrotoxic Drugs

Authors

  • Shaghayegh Sadat Esmaeilnejad Pediatric Department of Shahid Beheshti University of Medical Sciences and Health Services, Mofid Children Hospital, Tehran, Iran Author
  • Shiva Nazari Department of Pediatric Hematology and Oncology of Shahid Beheshti University of Medical Sciences and Health Services, Mofid Children Hospital, Tehran, Iran Author
  • Nasrin Esfandiar Department of Pediatric Nephrology of Shahid Beheshti University of Medical Sciences and Health Services, Mofid Children Hospital, Pediatric Nephrology Research Center, Research Institute for Children Health, Tehran, Iran Author

Abstract

Introduction. Children with malignancy who are under treatment with nephrotoxic drugs are at risk of renal dysfunction. Due to increased life expectancy, evaluation of drug toxicity is now of higher importance than before. The aim of this study is to compare two methods of GFR measurement. Methods. An analytical study on children with malignancy undergoing chemotherapy with nephrotoxic drugs (cisplatin, carboplatin, cyclophosphamide, ifosfamind, etoposide) during 2016 and 2017 in Mofid Children Hospital was done. Demographic information, anthropometric measurements, type of malignancy, type of chemotherapy medication and also lab tests including CBC and the biochemistry indices were recorded. The GFR of each patient was calculated using Schwartz formula and DTPA scanning. The rates were compared and the difference was analyzed statistically. Results. According to Schwartz formula, 24% of patients needed dose adjustment, while based on DTPA scanning, this rate was 6%. Comparing these two measures by paired T-test, showed a significant statistical difference (P < .05). Schwartz formula had 25.5% more positive results of predicting the need for dose adjustment. The two measured GFRs for each person were evaluated in terms of compatibility and correlation based on Kappa statistical method, which were incompatible and had significant difference (P < .05). Conclusion. Using evaluative methods including Schwartz formula cannot demonstrate renal dysfunctions reliability in patients taking nephrotoxic chemotherapy drugs. Eventually if the GFR measurement method overestimates patients with renal dysfunction, the patients will not be able to make adequate use of the therapeutic effects of chemotherapy with the appropriate dosage.

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Author Biographies

  • Shaghayegh Sadat Esmaeilnejad, Pediatric Department of Shahid Beheshti University of Medical Sciences and Health Services, Mofid Children Hospital, Tehran, Iran
    MD, Pediatric department of Shahid Beheshti University of medical sciences and health services, Mofid children Hospital, Tehran, Iran
  • Shiva Nazari, Department of Pediatric Hematology and Oncology of Shahid Beheshti University of Medical Sciences and Health Services, Mofid Children Hospital, Tehran, Iran
    Associate Professor of Pediatric Hematology and Oncology, department of Pediatric Hematology and Oncology of Shahid Beheshti University of medical sciences and health services, Mofid children Hospital, Tehran, Iran
  • Nasrin Esfandiar, Department of Pediatric Nephrology of Shahid Beheshti University of Medical Sciences and Health Services, Mofid Children Hospital, Pediatric Nephrology Research Center, Research Institute for Children Health, Tehran, Iran
    Assistant Professor of Pediatric Nephrology, department of Pediatric Nephrology of Shahid Beheshti University of medical sciences and health services, Mofid children Hospital, pediatric nephrology research center, research institute for children health, Tehran, Iran

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Published

2020-12-05

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Section

ORIGINAL | Kidney Diseases

How to Cite

Comparison Between eGFR by Schwartz Formula with Measured GFR by Radionuclide Diethylenetriamine Pentaacetic Acid Scan (Tc99 DTPA scan), in Patients Undergoing Chemotherapy with Nephrotoxic Drugs. (2020). Iranian Journal of Kidney Diseases, 14(6), 463-469. https://www.ijkd.org/index.php/ijkd/article/view/5246

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