Chemokine Receptor 2-V64I and Chemokine Receptor 5-Delta32 Polymorphisms and Clinical Risk Factors of Delayed Graft Function and Acute Rejection in Kidney Transplantation

Authors

  • Jalal Azmandian Physiology Research Center and Department of Nephrology, Urology and Renal Transplantation, Kerman University of Medical Sciences, Kerman and Nephrology Research Center, Tehran University of Medical Sciences, Tehran, Iran Author
  • Ali Mandegary Physiology Research Center and Department of Pharmacology and Toxicology, Faculty of Pharmacy, Kerman University of Medical Sciences, Kerman, Iran Author
  • Azadeh Saber Department of Nephrology, Urology and Renal Transplantation, Kerman University of Medical Sciences, Kerman, Iran Author
  • Maryam Torshabi Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran Author
  • Abbas Etminan Physiology Research Center and Department of Nephrology, Urology and Renal Transplantation, Kerman University of Medical Sciences, Kerman, Iran Author
  • Mohammad-Reza Ebadzadeh Physiology Research Center and Department of Nephrology, Urology and Renal Transplantation, Kerman University of Medical Sciences, Kerman, Iran Author
  • Faramarz Fazeli Department of Urology, Zahedan University of Medical Sciences, Zahedan, Iran Author
  • Samaneh Soleymani Department of Pharmacology and Toxicology, Faculty of Pharmacy, Kerman University of Medical Sciences, Kerman, Iran Author
  • Atefeh Taghipour Department of Pharmacology and Toxicology, Faculty of Pharmacy, Kerman University of Medical Sciences, Kerman, Iran Author
  • Mohammad-Ali Karimi Department of Pharmacology and Toxicology, Faculty of Pharmacy, Kerman University of Medical Sciences, Kerman, Iran Author

Abstract

Introduction. Chemokines and chemokine receptors have a pivotal role in immunity and inflammation. We aimed to evaluate their role in kidney transplant rejection.

Materials and Methods. The association of chemokine (C-C motif) receptor 2 (CCR2)-V64I and CCR5-Delta32 gene polymorphisms with acute rejection (AR) and delayed graft function (DGF) were examined in 100 donor-recipient pairs. The CCR2-V64I and CCR5-Delta32 alleles were determined using polymerase chain reaction and polymerase chain reaction-restriction fragment length polymorphism, respectively.

Results. No associations were found between donors or recipients' CCR2-V64I and CCR5-Delta32 gene polymorphisms and AR or DGF. Of the characteristics of the donors, recipients, and transplantation, glomerulonephritis as a cause of kidney failure in the recipients was weakly associated with AR (relative risk, 6.1; 95% confidence interval, 0.8 to 46.0; P = .07). Transplantation of kidney from females to males was weakly associated with DGF (relative risk, 5.5; 95% confidence interval, 0.9 to 33.0; P = .06). There was a significant association between AR, but not DGF, and graft loss in the patients (relative risk, 28.6; 95% confidence interval, 1.7 to 487.0; P = .03).

Conclusions. Our study failed to suggest CCR2-V64I or CCR5-Delta32 gene polymorphisms as risk factors for AR and DGF in kidney transplantation. Sex-matching between donors and recipients should be considered for living donor kidney transplantation.

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Published

2012-01-04

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Section

ORIGINAL | Transplantation

How to Cite

Chemokine Receptor 2-V64I and Chemokine Receptor 5-Delta32 Polymorphisms and Clinical Risk Factors of Delayed Graft Function and Acute Rejection in Kidney Transplantation. (2012). Iranian Journal of Kidney Diseases, 6(1), 56-62. https://www.ijkd.org/index.php/ijkd/article/view/607

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