Plasma Angiogenin and Vascular Endothelial Growth Factor A Among Hemodialysis Patients

Authors

  • Theodoros Eleftheriadis Department of Nephrology, Medical School, University of Thessaly, Larissa and Research Institute, Theagenion Anticancer Hospital, Thessaloniki, Greece Author
  • Georgia Antoniadi Department of Nephrology, Medical School, University of Thessaly, Larissa, Greece Author
  • Vassilios Liakopoulos Department of Nephrology, Medical School, University of Thessaly, Larissa, Greece Author
  • Georgios Pissas Department of Nephrology, Medical School, University of Thessaly, Larissa, Greece Author
  • Ioannis Stefanidis Department of Nephrology, Medical School, University of Thessaly, Larissa, Greece Author
  • Grammati Galaktidou Research Institute, Theagenion Anticancer Hospital, Thessaloniki, Greece Author

Abstract

Introduction. Angiogenesis plays a role in the pathogenesis of coronary heart disease (CHD) and diabetes mellitus (DM) pathology, and certain angiogenic factors are increased by inflammation. The aim of this study was to evaluate plasma angiogenin and vascular endothelial factor A (VEGFA) levels in hemodialysis patients, as well as the effect of CHD, DM, and inflammation on these markers.

Materials and Methods. Sixty-six hemodialysis patients were enrolled in the study, of whom 22 (33.3%) suffered from CHD , 22 (33.3%) from DM, and 28 (42.4%) from inflammation. They were compared with 24 healthy volunteers. Plasma angiogenin and VEGFA were assessed by means of enzyme-linked immunosorbent assay, and serum C-reactive protein was measured with an immunoturbidimetric method. These markers were compared between hemodialysis patients with and without CHD, DM, and inflammation.

Results. Compared to healthy volunteers, plasma angiogenin was significantly higher in hemodialysis patients (263.57 ± 65.95 ng/mL versus 499.15 ± 175.68 ng/mL; P < .001). Similarly, plasma VEGFA was markedly increased in hemodialysis patients (median, 60.50 pg/mL; range, 280 pg/mL), compared to healthy volunteers (median, 28.84 pg/mL; range, 59.40 pg/mL; P < .001). Neither angiogenin nor VEGFA levels differed significantly between hemodialysis patients with and without CHD, DM, or inflammation.

Conclusions. Plasma angiogenin and VEGFA levels are markedly increased in hemodialysis patients, but not associated with CHD, DM, or inflammation among hemodialysis patients.

Downloads

Download data is not yet available.

Downloads

Published

2012-05-02

Issue

Section

ORIGINAL | Dialysis

How to Cite

Plasma Angiogenin and Vascular Endothelial Growth Factor A Among Hemodialysis Patients. (2012). Iranian Journal of Kidney Diseases, 6(3), 209-215. https://www.ijkd.org/index.php/ijkd/article/view/659

Most read articles by the same author(s)