Efficacy and Safety of Turmeric Dietary Supplementation on Proteinuria in CKD: A Systematic Review and Meta-analysis of RCT

Authors

  • Leila Malekmakan Shiraz Nephro-Urology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran Author
  • Anahid Hamidianjahromi Shiraz Nephro-Urology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran Author
  • Mehrab Sayadi Cardiovascular Research Center, Shiraz University of Medical Sciences, Shiraz, Iran Author
  • Mohamad Hossein Rezazadeh Shiraz Nephro-Urology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran Author

Abstract

The beneficial effects of oral turmeric extract on proteinuria levels have been investigated in several human and animal studies. We conducted a systematic review and meta-analysis to evaluate the significance of this new treatment in CKD patients for the first time. We searched ISI Web of Science, PubMed/Medline, Google Scholar, Scopus, SID, and Magiran until March 2021 to identify human-controlled trials that evaluated the effect of turmeric on proteinuria in chronic kidney disease patients. A total of six trials met the selection criteria and were reviewed in our study and four of them were included in the meta-analysis. In these studies, the results showed not only a significant decrease in the level of proteinuria of the trial groups, who had received curcumin but also a significant change in the level of proteinuria between the trial and control groups (SMD = -0.72, 95% CI: -1.10 to 0.35). The results of this meta-analysis demonstrates that turmeric/curcumin oral supplementation significantly improves urinary protein excretion in patients who suffer from chronic kidney diseases with proteinuria; thus, it can be considered as a potential treatment modality in this population.

 

DOI: 10.52547/ijkd.6772

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Published

2022-06-14

Issue

Section

REVIEW | Kidney Diseases

How to Cite

Efficacy and Safety of Turmeric Dietary Supplementation on Proteinuria in CKD: A Systematic Review and Meta-analysis of RCT. (2022). Iranian Journal of Kidney Diseases, 16(3), 153-161. https://www.ijkd.org/index.php/ijkd/article/view/6772

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