Contrast-induced Nephropathy in Kidney Transplant Recipients: A Single-center Experience

Authors

  • Osama A Gheith The Nephrology Department, Hamed Al-Essa Organ Transplant Center, Sabah Area, Kuwait Author
  • Ayman M Nagib The Nephrology Department, Hamed Al-Essa Organ Transplant Center, Sabah Area, Kuwait Author
  • Medhat A Halim The Nephrology Department, Hamed Al-Essa Organ Transplant Center, Sabah Area, Kuwait Author
  • Tarek Mahmoud The Nephrology Department, Hamed Al-Essa Organ Transplant Center, Sabah Area, Kuwait Author
  • Prasad Nair The Nephrology Department, Hamed Al-Essa Organ Transplant Center, Sabah Area, Kuwait Author
  • Hasaneen Abo-Atya The Nephrology Department, Hamed Al-Essa Organ Transplant Center, Sabah Area, Kuwait Author
  • Mohamed Shaker The Nephrology Department, Hamed Al-Essa Organ Transplant Center, Sabah Area, Kuwait Author
  • Mohamed Mostafa The Nephrology Department, Hamed Al-Essa Organ Transplant Center, Sabah Area, Kuwait Author
  • Hosam Attia Radiology Department, Ibn Sina Hospital, Sabah Area, Kuwait Author
  • Torki Alotaibi The Nephrology Department, Hamed Al-Essa Organ Transplant Center, Sabah Area, Kuwait Author

Abstract

Introduction. Data regarding contrast-induced nephropathy (CIN) in kidney transplant (KT) recipients are scarce despite the distinct risk factors such as the use of immunosuppressive agents, sympathetic denervation, glomerular hyperfiltration, and high prevalence of the cardiovascular disease. This study aimed to determine the prevalence of CIN in KT recipients who received low-osmolality iodine-based contrast material (CM) for radiological assessment. Methods. Between 2010 and 2020, 79 of the 3180 KT recipients followed at Hamed Al-Essa organ transplant center received low-osmolality iodine-based contrast for radiological assessment for various indications. Preventive measures including holding metformin, intravenous hydration, sodium bicarbonate and N-acetylcysteine were given before contrast administration. CIN was defined as an increase in serum creatinine of 25% from the baseline within 72 hours. Results. The enrolled patients were divided into two groups: those who developed CIN (n = 7) and those with no increase in serum creatinine level (n = 72). The mean age of the patients was 52.1 ± 12.3 years; 44 of them were males, and the cause of end-stage kidney disease was mostly diabetic nephropathy. The pre-transplant demographics were comparable between the two groups. Fortyseven cases received contrast for coronary angiography, and 32 received it for a CT scan. The graft function deteriorated in group 1, but no significant difference was found between the two groups at the end of the study. Conclusion. CIN is not uncommon in KT recipients receiving CM, especially with ischemic heart disease. Risk stratification, optimizing hemodynamics, and avoiding potential nephrotoxins are essential before performing CM-enhanced studies in KT recipients.

 

DOI: 10.52547/ijkd.7165

Downloads

Download data is not yet available.

Downloads

Published

2023-02-01

Issue

Section

ORIGINAL | Transplantation

How to Cite

Contrast-induced Nephropathy in Kidney Transplant Recipients: A Single-center Experience. (2023). Iranian Journal of Kidney Diseases, 17(1), 47-53. https://www.ijkd.org/index.php/ijkd/article/view/7165