Roles of Clinical Features and Chest CT in Predicting the Outcomes of Hospitalized Patients with COVID-19 Developing AKI

Authors

  • Tahereh Sabaghian Clinical Research Development Center, Imam Hossein Teaching Hospital, Shahid Beheshti University of Medical Sciences, Madani Ave., Tehran, Iran
  • Masoomeh Raoufi Department of Radiology, Imam Hossein Teaching Hospital, Shahid Beheshti University of Medical Sciences, Madani Ave., Tehran, Iran
  • Shekoofeh Yaghmaei University of Fribourg, Av. de l’Europe 20, 1700 Fribourg, Switzerland
  • Omid Moradi Department of Clinical Pharmacy, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Vali Asr St., Niayesh Cross Section, Tehran, Iran
  • Azamalsadat Alavi Department of Radiology, Imam Hossein Teaching Hospital, Shahid Beheshti University of Medical Sciences, Madani Ave., Tehran, Iran
  • Hemmat Ebrat Balkhkanlou Department of Radiology, Imam Hossein Teaching Hospital, Shahid Beheshti University of Medical Sciences, Madani Ave., Tehran, Iran
  • Farnoosh Masbough Department of Clinical Pharmacy, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Vali Asr St., Niayesh Cross Section, Tehran, Iran
  • Ali Falsafi Swiss Federal Institute of Technology Lausanne, Rte Cantonale, 1015 Lausanne, Switzerland
  • Minoo Heidari Almasi Clinical Research Development Center, Imam Hossein Teaching Hospital, Shahid Beheshti University of Medical Sciences, Madani Ave., Tehran, Iran

Abstract

This research aimed to evaluate the clinical features and computed tomography (CT) scans associated with poor outcomes in COVID-19 patients with acute kidney injury (AKI). A total of 351 COVID-19 patients (100 AKI, 251 non-AKI) hospitalized at Imam Hossein Teaching Hospital affiliated to Shahid Beheshti University of Medical Sciences were included. To investigate the factors associated with in-hospital mortality in COVID-19 patients developing AKI, COX univariate and multivariate regression models were applied after controlling other confounding variables. C-reactive protein CRP, lactate, and procalcitonin levels were significantly higher in AKI patients than in non-AKI patients (P < .05). In addition, AKI patients had higher frequencies of lymphopenia and leukocytosis (P < .05). The troponin levels and WBC were the most significant factors for predicting mortality in patients with AKI. Our findings showed that AKI per se is much more important than any other prognostic factor affecting non-AKI patients. However, AKI patients with higher CRP, PCT, and lactate levels had a poor prognosis.

 

DOI: 10.52547/ijkd.7241

Author Biography

  • Shekoofeh Yaghmaei, University of Fribourg, Av. de l’Europe 20, 1700 Fribourg, Switzerland

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Published

2023-02-01

Issue

Section

BRIEF COMMUNICATION | Kidney diseases