Relationship Between Serum Intact Parathyroid Hormone and Pruritus in Hemodialysis Patients

Authors

  • Atieh Makhlough Research Center for Molecular and Cellular Biology, Faculty of Medicine and Division of Nephrology, Mazandaran University of Medical Sciences, Sari, Iran Author
  • Naser Emadi Department of Dermatology, Mazandaran University of Medical Sciences, Sari, Iran Author
  • Omid Sedighi Division of Nephrology, Mazandaran University of Medical Sciences, Sari, Iran Author
  • Mohamad Khademloo Department of Epidemiology, Mazandaran University of Medical Sciences, Sari, Iran Author
  • Amir Reza Bicmohamadi Department of Community Medicine, Mazandaran University of Medical Sciences, Sari, Iran Author

Abstract

Introduction. Pruritus is one of the most common cutaneous complications in hemodialysis patients. There is no consensus on etiologic and pathologic factors. This study is aimed to evaluate the correlation between serum intact parathyroid hormone (PTH) level and the severity of pruritus in hemodialysis patients.

Materials and Methods. In a cross-sectional study, all of the patients referred to hemodialysis center of two hospitals in Sari, Iran, were primarily examined by a dermatologist and those who had no pathologic findings were included in the study. Serum levels of calcium, phosphorus, albumin, creatinine, and intact PTH were measured and evaluated against the pruritus scores.

Results. A total of 153 patients were studied of whom 52.3% (n = 80) were men. The prevalence of pruritus and hyperparathyroidism were 61.4% and 60.7%, respectively, and these were not significantly different between men and women. There was a significant difference in the mean itching score between the patents with and without hyperparathyroidism (5.71 ± 5.39 and 4.93 ± 2.93, respectively; P = .005). Serum intact PTH level correlated with itching score in this population (r = 0.294, P < .001), while no correlations were found between itching score and other laboratory parameters.

Conclusions. Our study showed that intact PTH level is correlated to the severity of pruritus in hemodialysis patients. Therefore, control of hyperparathyroidism in hemodialysis patients is very important to overcome pruritus.

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Author Biographies

  • Atieh Makhlough, Research Center for Molecular and Cellular Biology, Faculty of Medicine and Division of Nephrology, Mazandaran University of Medical Sciences, Sari, Iran
    Associate professor of nephrology, Mazandaran university of medical sciences
  • Naser Emadi, Department of Dermatology, Mazandaran University of Medical Sciences, Sari, Iran
    Assistant professor of dermatology, Mazandaran university of medical sciences
  • Omid Sedighi, Division of Nephrology, Mazandaran University of Medical Sciences, Sari, Iran

    Assistant professor of nephrology, Mazandaran university of medical sciences

  • Mohamad Khademloo, Department of Epidemiology, Mazandaran University of Medical Sciences, Sari, Iran
    Associate professor of community medicine department in mazandaran university of medical sciences
  • Amir Reza Bicmohamadi, Department of Community Medicine, Mazandaran University of Medical Sciences, Sari, Iran
    General physician , Mazandaran university of medical sciences

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Published

2013-01-13

Issue

Section

ORIGINAL | Dialysis

How to Cite

Relationship Between Serum Intact Parathyroid Hormone and Pruritus in Hemodialysis Patients. (2013). Iranian Journal of Kidney Diseases, 7(1), 42-46. https://www.ijkd.org/index.php/ijkd/article/view/773

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