Ki-67 Proliferation Index in Renal Biopsy Samples of Patients With Systemic Lupus Erythematosus and Its Correlation with Clinical Findings

Authors

  • Ediz Dalkilic Division of Rheumatology, Department of Internal Medicine, Uludag University Faculty of Medicine, Bursa, Turkey Author
  • Gulaydan Filiz Department of Pathology, Uludag University Faculty of Medicine, Bursa, Turkey Author
  • Mahmut Yavuz Division of Nephrology, Department of Internal Medicine, Uludag University Faculty of Medicine, Bursa, Turkey Author
  • Kamil Dilek Division of Nephrology, Department of Internal Medicine, Uludag University Faculty of Medicine, Bursa, Turkey Author
  • Alparslan Ersoy Division of Nephrology, Department of Internal Medicine, Uludag University Faculty of Medicine, Bursa, Turkey Author
  • Mustafa Yurtkuran Division of Nephrology, Department of Internal Medicine, Uludag University Faculty of Medicine, Bursa, Turkey Author
  • Aysegul Oruc Division of Nephrology, Department of Internal Medicine, Uludag University Faculty of Medicine, Bursa, Turkey Author
  • Cuma Bulent Gul Uludag University Faculty of MedicineDivision of Nephrology, Department of Internal Medicine, Uludag University Faculty of Medicine, Bursa, Turkey Author
  • Mustafa Gullulu Division of Nephrology, Department of Internal Medicine, Uludag University Faculty of Medicine, Bursa, Turkey Author

Abstract

Introduction. Systemic lupus erythematosus is an autoimmune disease that may affect almost all organ systems. Renal involvement is the most significant prognostic factor. Renal biopsy findings play an important role in treatment decision. Ki-67 is a monoclonal antibody that is only found in proliferative cells. This study aimed to investigate the proliferative activity in renal biopsy specimens of patients with lupus nephritis using the Ki-67 monoclonal antibody, and to compare the proliferative index between different subgroups of patients.

Materials and Methods. Renal biopsy specimens of 29 patients with systemic lupus erythematosus were retrospectively evaluated. Type of lupus nephritis and activity and chronicity indexes were determined. Ki-67 immunostaining was performed. For each patient, 1000 cells were counted and the number of Ki-67 positive cells was determined. The Ki-67 activity index was compared between different subgroups of lupus nephritis and correlated with systemic lupus erythematosus disease activity index, serum creatinine, proteinuria, anticardiolipin antibodies, and complement levels.

Results. A positive correlation between Ki-67 proliferation index, serum creatinine levels, and systemic lupus erythematosus disease activity index were found. Although conventional activity indexes were low, in 3 of 9 patients with class II lupus nephritis, Ki-67 proliferation indexes were high, indicating proliferation.

Conclusions. Ki-67 can be used as a proliferation marker in renal biopsy specimens for patients diagnosed with systemic lupus erythematosus.

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Author Biographies

  • Ediz Dalkilic, Division of Rheumatology, Department of Internal Medicine, Uludag University Faculty of Medicine, Bursa, Turkey
    Department of Internal Medicine, Rheumatology Division
  • Mahmut Yavuz, Division of Nephrology, Department of Internal Medicine, Uludag University Faculty of Medicine, Bursa, Turkey
    Department of Internal Medicine, Nephrology Division
  • Kamil Dilek, Division of Nephrology, Department of Internal Medicine, Uludag University Faculty of Medicine, Bursa, Turkey
    Department of Internal Medicine, Nephrology Division
  • Alparslan Ersoy, Division of Nephrology, Department of Internal Medicine, Uludag University Faculty of Medicine, Bursa, Turkey
    Department of Internal Medicine, Nephrology Division
  • Mustafa Yurtkuran, Division of Nephrology, Department of Internal Medicine, Uludag University Faculty of Medicine, Bursa, Turkey
    Department of Internal Medicine, Nephrology Division
  • Aysegul Oruc, Division of Nephrology, Department of Internal Medicine, Uludag University Faculty of Medicine, Bursa, Turkey
    Department of Internal Medicine, Nephrology Division
  • Cuma Bulent Gul, Uludag University Faculty of MedicineDivision of Nephrology, Department of Internal Medicine, Uludag University Faculty of Medicine, Bursa, Turkey
    Department of Internal Medicine, Nephrology Division
  • Mustafa Gullulu, Division of Nephrology, Department of Internal Medicine, Uludag University Faculty of Medicine, Bursa, Turkey
    Department of Internal Medicine, Nephrology Division

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Published

2013-05-20

Issue

Section

ORIGINAL | Kidney Diseases

How to Cite

Ki-67 Proliferation Index in Renal Biopsy Samples of Patients With Systemic Lupus Erythematosus and Its Correlation with Clinical Findings. (2013). Iranian Journal of Kidney Diseases, 7(3), 198-203. https://www.ijkd.org/index.php/ijkd/article/view/823

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