The Effect of Dexmedetomidine Pre-treatment on Postoperative Cognitive Dysfunction in Elderly Patients Undergoing General Anesthesia for Orthopedic Surgery
DOI:
https://doi.org/10.52547/bt9jbt12Keywords:
General anesthesiaAbstract
Objective: To investigate the intervention effect of edaravone pretreatment before general anesthesia and its effect on the incidence of postoperative cognitive dysfunction (POCD) in elderly patients undergoing orthopedic surgery. Methods: A total of 94 elderly patients undergoing orthopedic surgery from June 2021 to June 2023 were selected and divided into a control group and an observation group by envelope method, with 47 cases in each group. The control group was injected with the same amount of normal saline before anesthesia induction, and the observation group was intravenously injected with edaravone before anesthesia induction. The effect of the two groups was evaluated 5 days after anesthesia, and the patients were followed up for 3 months. The Mini-mental State Examination (MMSE) score, visual analogue scale (VAS) score, inflammatory response, postoperative cognitive dysfunction (POCD) and incidence of adverse reactions were compared between the two groups. Results: Both groups were accompanied by different degrees of cognitive impairment at different time points after operation. The MMSE scores of the observation group on the 1st, 3rd and 5th day after operation were higher than those of the control group (P<0.05). The VAS scores of the observation group at different time points after operation were lower than those of the control group (P<0.05). Both groups were accompanied by varying degrees of inflammation and pain mediators after operation. IFN-γ in the observation group was higher than that in the control group (P<0.05). The levels of IL-4, SP and β-EP were lower than those in the control group (P<0.05). The incidence of POCD in the observation group was lower than that in the control group (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion: Edaravone pretreatment before general anesthesia in elderly patients undergoing orthopedic surgery can help reduce the impact on the cognitive level of patients, relieve pain and inflammatory response, and reduce the incidence of POCD, with high drug safety, which is worthy of promotion and application.
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