Correlation Between Ankle-Brachial Index and Microalbuminuria in Type 2 Diabetes Mellitus

Authors

  • Khadijeh Makhdoomi Nephrology and Kidney Transplant Research Center and Department of Nephrology, Urmia University of Medical Sciences, Urmia, Iran Author
  • Afshin Mohammadi Department of Radiology, Urmia University of Medical Sciences, Urmia, Iran Author
  • Zahra Yekta Department of Social Medicine, Urmia University of Medical Sciences, Urmia, Iran Author
  • Mohammad Reza Aghasi Department of Endocrinology, Urmia University of Medical Sciences, Urmia, Iran Author
  • Nader Zamani Department of Internal Medicine, Urmia University of Medical Sciences, Urmia, Iran Author
  • Sara Vossughian Department of Internal Medicine, Urmia University of Medical Sciences, Urmia, Iran Author

Abstract

Introduction. Microalbuminuria is a reliable marker of diabetic nephropathy. Establishment of peripheral vascular complications leads to early diagnosis, prevention, and treatment of renal and cardiovascular complications. This study investigated the value of ankle-brachial index (ABI) for prediction of microalbuminuria in type 2 diabetic patients.

Materials and Methods.  Measurement of ABI with color Doppler ultrasonography was carried out for 206 patients with type 2 diabetes mellitus. An ABI Index less than 0.9 was defined as a predictive marker for atherosclerosis. Microalbuminuria and risk factors of atherosclerosis were compared between the patients categorized based on the ABI values.

Results. The mean ABI was 1.1 ± 0.2 (range, 0.052 to 1.6), and 41 (20%) had an abnormal ABI (<  0.9). The correlations were significant between abnormal ABI and duration of disease (P = .04), cardiovascular event and cardiac care unit admission (P = .001), hypertension (P = .01), and dyslipidemia (P = .01). There was a significant correlation between ABI and microalbuminuria (odds ratio, 0.05; 95% confidence interval, 0.038 to 0.630; P < .001). A cutoff point of an ABI less than or equal to 1.04 had a sensitivity of 71.6% and a specificity of 64.2% for prediction of microalbuminuria.

Conclusions. The ABI is a noninvasive and reliable assay for detection of peripheral and cardiovascular complications, and also early stage of nephropathy in diabetic patients. In patients with an abnormal ABI, long-term follow-up for earlier detection and prevention of complications is helpful.

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Author Biography

  • Khadijeh Makhdoomi, Nephrology and Kidney Transplant Research Center and Department of Nephrology, Urmia University of Medical Sciences, Urmia, Iran
    nephrology department of urmia university

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Published

2013-05-20

Issue

Section

ORIGINAL | Kidney Diseases

How to Cite

Correlation Between Ankle-Brachial Index and Microalbuminuria in Type 2 Diabetes Mellitus. (2013). Iranian Journal of Kidney Diseases, 7(3), 204-209. https://www.ijkd.org/index.php/ijkd/article/view/849

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