Vol. 9 No. 6 (2015): November
About the cover:Deletion of cyclic AMP response element-binding protein (CREB) in renin cells does not alter basal renin expression in adult kidney, but influence renin recruitment in low-sodium diet mice kidney. Top two rows are immunostaining for renin and CREB in consecutive sections of kidneys from wild type and CREB gene knock out mice, respectively. In wild type kidney, renin cells are positive for CREB (brown nuclei), but in CREB knock out kidney, CREB is absent (blue nuclei). Bottom two rows are immunostaining for renin in wild type and CREB knock out mice with normal and low-sodium diet, respectively. In wild type mice, renin staining increased in low-sodium diet kidney compared with normal diet. By contrast, in CREB knock out mice renin staining did not increase or even decreased in low-sodium diet kidney.
