Successful Treatment of Mucormycosis After Kidney Transplantation

Authors

  • Amirhossein Miladipour Division of Nephrology, Department of Internal Medicine, Shohada-e-Tajrish Hospital, Shahid Beheshti University (MC), Tehran, Iran
  • Esmat Ghanei Division of Nephrology, Department of Internal Medicine, Shohada-e-Tajrish Hospital, Shahid Beheshti University (MC), Tehran, Iran
  • Alireza Nasrollahi Division of Nephrology, Department of Internal Medicine, Shohada-e-Tajrish Hospital, Shahid Beheshti University (MC), Tehran, Iran
  • Habibollah Moghaddasi Department of Head and Neck Surgery, Loghman-e-Hakim Hospital, Shahid Beheshti University (MC), Tehran, Iran

Abstract

Fungal infections are rare but represent serious complications following organ transplantation. We present a case of mucormycosis primarily affecting the paranasal sinuses in a 51-year-old man with a kidney allograft. The patient presented with headache, left facial and orbital pain, nasal discharge, and elevation of serum creatinine 18 months after kidney transplantation. Laboratory tests revealed cyclosporine nephrotoxicity, cytomegalovirus infection, and prediabetes. Imaging findings were compatible with left maxillary, ethmoidal, and sphenoidal sinusitis. Diagnosis was made based on pathologic findings and detection of typical fungal hyphea in the infected tissues. The patient was successfully treated by discontinuation of cyclosporine and mycophenolate mofetil, initiation of systemic amphotericin B, and aggressive surgical debridement.

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Published

2009-04-19

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Section

CASE REPORT | Transplantation