Role of Renin-Angiotensin-Aldosterone System Gene Polymorphisms andHypertension-induced End-stage RenalDisease in Autosomal Dominant Polycystic Kidney Disease

Authors

  • Gnanasambandan Ramanathan Department of Biomedical Sciences, Sri Ramachandra University, Chennai, India
  • Ramprasad Elumalai Department of Nephrology, Sri Ramachandra University, Chennai, India
  • Soundararajan Periyasamy Department of Nephrology, Sri Ramachandra University, Chennai, India
  • Bhaskar Lakkakula Department of Biomedical Sciences, Sri Ramachandra University, Chennai; Sickle Cell Institute Chhattisgarh, Raipur, India

Abstract

Autosomal dominant polycystic kidney disease (ADPKD) is the most common inherited disease of the kidneys and is marked by progressive cyst growth and decline in kidney function, resulting in end-stage renal disease (ESRD). Hypertension is thought to be a significant modifying factor in the progression of renal failure in ADPKD. A number of genetic variations involved in renin-angiotensin-aldosterone system (RAAS) pathway genes have clinical or physiological impacts on pathogenesis of hypertension-induced ESRD in ADPKD. Information on RAAS pathway gene polymorphisms and their association with ESRD and ADPKD, published till March 2013, was collected using MEDLINE search. The present review deals with RAAS gene polymorphisms focused on hypertension-induced ESRD in ADPKD in different populations. The results were inconclusive and limited by heterogeneity in the study designs and the population stratification. In lieu of applying next generation sequencing technologies to study complex diseases, it is also possible to apply the same to unravel the complexity of ESRD in ADPKD.

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Published

2014-06-18

Issue

Section

REVIEW | Kidney Diseases