Nephrotoxic Effect of Aspartame as an Artificial Sweetener: a Brief Review

Authors

  • Mohammad Reza Ardalan Kidney Research Center, Tabriz University of Medical Sciences, Tabriz, Iran Author
  • Hadi Tabibi Department of Human Nutrition, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Tehran, Iran Author
  • Vahideh Ebrahimzadeh Attari Kidney Research Center, Tabriz University of Medical Sciences, Tabriz, Iran Author
  • Aida Malek Mahdavi Connective Tissue Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran Author

Abstract

Aspartame is one of the most popular artificial sweeteners over the world. Although its consumption is considered to be safe in acceptable daily intake ranges which were set by the United States Food and Drugs Administration and other regulatory agencies, there are lots of controversies regarding its safety nowadays. Some of the recent experimental and epidemiological studies showed that consumption of aspartame may causes some adverse health effects including obesity, metabolic syndrome, and alteration in gut microbiota. Moreover, studies on the nephrotoxic effect of aspartame have increased. A search of several literature databases for publications on adverse effects of aspartame on the kidney function from 1980 to 2016 showed that long-term consumption of aspartame led to a dose-dependent increased production of free radicals in renal tissues as well as kidney injury, based on several studies on animals However, given the lack of clinical data in this area, it is difficult to make a definitive conclusion regarding nephrotoxic effect of aspartame. Overall, consumers should be aware of the potential side effects of aspartame and other artificial sweeteners. At present it may be recommended that only a minimal amount of them would be consumed.

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Published

2017-10-15

Issue

Section

BRIEF REVIEW | Kidney Diseases

How to Cite

Nephrotoxic Effect of Aspartame as an Artificial Sweetener: a Brief Review. (2017). Iranian Journal of Kidney Diseases, 11(5), 339-343. https://www.ijkd.org/index.php/ijkd/article/view/3006

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