Sofosbuvir and Daclatsvir in Treatment of Hepatitis C Virus-related Membranoproliferative Glomerulonephritis With Cryoglobulinemia in a Patient With Hepatitis C Genotype 4

Authors

  • Ahmed Yahia Elmowafy Urology and Nephrology Center, Mansoura University, Egypt
  • Hanzada Mohamed El Maghrabi Urology and Nephrology Center, Mansoura University, Egypt
  • Mohamed Ahmed Zahab Urology and Nephrology Center, Mansoura University, Egypt
  • Salwa Mahmoud Elwasif Urology and Nephrology Center, Mansoura University, Egypt
  • Mohamed Adel Bakr Urology and Nephrology Center, Mansoura University, Egypt

Abstract

Direct antivirals showed dramatic response in hepatitis C virus (HCV) eradication, but their effect on extrahepatic manifestations is still unclear. A 49-year-old woman was referred to us suffering from lower limb edema and frothy urine. Renal biopsy was done and she was diagnosed with HCV-related membranoproliferative glomerulonephritis with cryoglobulinemia. Treatment with interferon plus ribavirin, steroid, and cyclophosphamide was tried but failed. After introduction of a sofosbuvir-based regimen to the treatment, sustained virologic response was achieved and nephrotic syndrome remission was induced successfully. We could conclude that HCV-related membranoproliferative glomerulonephritis with cryoglobulinemia could be treated successfully with immunosuppressive drugs plus sofosbuvir and dacalatasvir.

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Published

2018-10-15

Issue

Section

CASE REPORT | Kidney Diseases