Cellular and Molecular Aspects of Goodpasture Syndrome


  • Faris Q Alenzi College of Applied Medical Sciences, Prince Salman University, Al-Kharj, Saudi Arabia Author
  • Mohamed L Salem Department of Zoology, Faculty of Science, Tanta University, Egypt Author
  • Fawwaz A Alenazi Department of Pediatrics, King Fahad Medical City, Riyadh, Saudi Arabia Author
  • Richard K Wyse Department of Surgery, Imperial College of Medicine, London, UK Author


Goodpasture syndrome, a rare human autoimmune disorder, is characterized by the presence of pathogenic autoantibodies that react with the components of the glomerular basement membrane. The clinical condition of the Goodpasture syndrome is characterized by an acute necrotizing glomerulonephritis, often with accompanying pulmonary hemorrhage. Notably, the Goodpasture antigen has been localized to the noncollagenous domain of the alpha3 chain of type IV collagen. Additionally, human leukocyte antigen-DR2, and to a lesser extent human leukocyte antigen-DR4, have been identified as important restriction elements.  The role of T cells in Goodpasture syndrome is indicated by the highly restricted specificity of the antibody response and the strong major histocompatibility complex class II association. In this review article, we briefly describe the latest views on the molecular and cellular themes of Goodpasture syndrome.


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REVIEW | Kidney Diseases

How to Cite

Cellular and Molecular Aspects of Goodpasture Syndrome. (2012). Iranian Journal of Kidney Diseases, 6(1), 1-8. https://www.ijkd.org/index.php/ijkd/article/view/571