Bioengineered Kidney, Still a Long Way to Go

Abstract

Regenerative medicine has attempted to raise hopes to replace failing solid organs as a part of its wide-spectrum mission over the last couple of decades. To generate and implant an organ, taking the global challenge of organ shortage and histological complexity into consideration, has made this endeavor more taxing and strenuous in comparison with other subjects including cells and tissues. As the most prevalent transplanting organ worldwide, to make a kidney in laboratories using decellularized discarded donated kidney as a scaffold and recullalarize that with recipient’s native cells to circumvent another unavoidable obstacle, immunological mismatch, has remained a not yet attainable promise. Diversity of cell types and structural complexity of kidney with a range of functions has slowed down the pace of taking steps to fulfill this outstanding ambition, and, accordingly, it would make sense for the nonce that main attempts in limited-funding settings shall be directed to procure more allogenic grafts to partially meet the daily-expanding demands.