Effect of Herbal Medicine Achillea Millefolium on Plasma Nitrite and Nitrate Levels in Patients With Chronic Kidney Disease: A Preliminary Study

Authors

  • Sepideh Vahid Drug Design and Development Research Center, Tehran University of Medical Sciences, Tehran, Iran Author
  • Simin Dashti-Khavidaki Department of Clinical Pharmacy, School of Pharmacy and Nephrology Research Center, Imam-Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran Author
  • Farrokhlegha Ahmadi Nephrology Research Center, and Division of Nephrology, Imam-Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran Author
  • Mohsen Amini Drug Design and Development Research Center and Department of Medicinal Chemistry, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran Author
  • Mohammad Hosein Salehi Surmaghi Department of Pharmacognosy, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran Author

Abstract

Introduction. Increased plasma nitric oxide concentration has been supposed as one of the possible mechanisms of bleeding tendency in patients who suffer chronic kidney disease. Nitric oxide-scavenging properties have been reported with some Achillea species. This study was designed to find any possible effect of Achillea millefolium on plasma nitric oxide concentration in these patients.

Materials and Methods. Thirty-one chronic kidney disease patients were included in this randomized controlled trial, of whom16 received 1.5 g of powdered A millefolium flower 3 days a week for 2 months, and 15 received placebo for the same period. Plasma samples were collected before and after the study period to estimate the effect of A millefolium on plasma nitric oxide metabolites (nitrite and nitrate).

Results. Although not statistically significant, plasma nitrite and nitrate concentrations decreased after 2 months' administration of A millefolium (0.82 ± 0.51 µmol/L to 0.63 ± 0.42 µmol/L and 50.55 ± 17.92 µmol/L to 44.09 ± 17.49 µmole/L, respectively). These concentrations were slightly increased in the placebo group after the study period.

Conclusions. Countercurrent to the placebo group, plasma nitric oxide metabolites were marginally decreased after A millefolium administration in chronic kidney disease patients. Higher doses or longer duration of plant administration may make these changes more significant.

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Published

2012-09-11

Issue

Section

ORIGINAL | Kidney Diseases

How to Cite

Effect of Herbal Medicine Achillea Millefolium on Plasma Nitrite and Nitrate Levels in Patients With Chronic Kidney Disease: A Preliminary Study. (2012). Iranian Journal of Kidney Diseases, 6(5), 350-354. https://www.ijkd.org/index.php/ijkd/article/view/704

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