Montelukast Is Effective in Treating Rhabdomyolysis Due to Intoxication: A Randomized Clinical Trial

Authors

  • Mohsen Bijandi School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran Author
  • Mitra Rahimi Toxicological Research Center, Excellence Center and Department of Clinical Toxicology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran Author
  • Shahin Shadnia Toxicological Research Center, Excellence Center and Department of Clinical Toxicology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran Author
  • Babak Mostafazadeh Toxicological Research Center, Excellence Center and Department of Clinical Toxicology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran Author
  • Latif Gachkar Department of Infectious Disease, School of Medicine, Loghman Hakim Hospital, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran Author
  • Maral Ramezani Department of Pharmacology, School of Medicine, Arak University of Medical Sciences, Arak, Iran Author
  • Peyman Erfan Talab Evini Toxicological Research Center, Excellence Center and Department of Clinical Toxicology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran Author

Abstract

Introduction. Rhabdomyolysis is a clinical syndrome accompanied with biochemical changes that is diagnosed in some patients with acute chemical or drug poisoning. In this regard, the present study aimed to evaluate the effects of Montelukast in the treatment of intoxication-induced rhabdomyolysis. Methods. This single-blind randomized clinical trial study was conducted in Loghman Hakim Hospital from March 2021 to March 2022. The study participants were 60 individuals evenly distributed into experimental and control groups. The experimental group received Montelukast plus routine treatment and the control group Creatine phosphokinase (CPK), urea, creatinine, aspartate aminotransferase (AST) and alanine transaminase (ALT) levels were monitored daily in both groups for seven days. The variables of age, gender and history of diabetes mellitus and kidney diseases were recorded. Results. The mean age was 39.9 ± 16.87 and 38.2 ± 16.3 years in the control and intervention groups, respectively. Montelukast significantly (P < .05) reduced CPK levels on days five and seven, urea on days three, four, five and seven, and creatinine on days two to seven. The AST and ALT levels, unlike the control group which has a decreasing trend, increased first in the Montelukast group and then decreased on the sixth and seventh days. Conclusion. The results showed that Montelukast effectively reduced CPK, urea and creatinine levels, as well as the recovery time in patients with poison-induced rhabdomyolysis. In other words, Montelukast is effective in the treatment of rhabdomyolysis.

 

DOI: 10.52547/ijkd.7222

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Published

2023-08-24

Issue

Section

ORIGINAL | Kidney Diseases

How to Cite

Montelukast Is Effective in Treating Rhabdomyolysis Due to Intoxication: A Randomized Clinical Trial. (2023). Iranian Journal of Kidney Diseases, 17(4), 199-204. https://www.ijkd.org/index.php/ijkd/article/view/7222