Cloxacillin as an Antibiotic Lock Solution for Prevention of Catheter-Associated Infection

Authors

  • Mozhgan Davanipur Department of Internal Medicine, Nemazi Hospital, Shiraz University of Medical Sciences, Shiraz, Iran
  • Maryam Pakfetrat Division of Nephrology, Department of Internal Medicine, Nemazi Hospital, Shiraz University of Medical Sciences, Shiraz, Iran
  • Jamishid Roozbeh Division of Nephrology, Department of Internal Medicine, Nemazi Hospital, Shiraz University of Medical Sciences, Shiraz, Iran

Abstract

Introduction. Catheter-related infection is associated with increased all-cause mortality and morbidity in hemodialysis patients. This study aimed to evaluate an antimicrobial lock solution (cloxacillin and heparin) in temporary noncuffed double-lumen catheters for long-term intermittent hemodialysis as a method of preventing catheter-related infection.

Materials and Methods. Patients on hemodialysis with noncuffed temporary double lumen catheter were randomly divided into 2 groups. Fifty patients received a solution containing cloxacillin, 100 mg/mL, plus heparin, 1000 IU/mL as a 2.5-mL solution instilled in each of catheter lumens after dialysis session. Another 50 patients received only heparin. They were allowed to dwell until the next session of dialysis.

Results. One catheter-related bacteremia was observed in the antibiotic group whereas catheter-related bacteremia was observed in 8 of those who received heparin only. The rate of catheter-related bacteremia episodes were 0.5 per 1000 catheter-days in the antibiotic group versus 7.8 per 1000 catheter-days in the control group (P = .02).

Conclusions. In the present study, application of cloxacillin as antibiotic lock solution for dialysis catheters resulted in a considerable reduction in catheter-related bacteremia rate.

Author Biography

  • Mozhgan Davanipur, Department of Internal Medicine, Nemazi Hospital, Shiraz University of Medical Sciences, Shiraz, Iran

    internal medicine resident

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Published

2011-08-29

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Section

ORIGINAL | Dialysis