Patient and Graft Outcomes in Deceased-Donor Kidney Transplantation: A good Start for a Promising Future

Abstract

Introduction. Kidney transplantation from deceased donor has progressively increased in Iran; however, there are limited published data on its outcome. We evaluated the short-term outcome of kidney transplants using deceased donors in Iran.

Materials and Methods. A total of 121 adult patients who received a kidney allograft from a deceased donor in Baqiyatallah Transplant Center were enrolled. The following data were collected: age, gender, body mass index, cold and warm ischemia times, history of dialysis and blood transfusion, blood pressure, panel reactive antibodies, episodes of acute rejection, acute tubular necrosis, serum creatinine concentration, and surgical complications.

Results. The median age of the kidney allograft recipients was 48 years (range, 16 to 71 years). Male gender was predominant (n = 82) with slightly better patient and graft survivals without significant differences. The mean cold ischemic time was 190 ± 50 minutes (range, 1.5 to 4.7 hours). One- and 2-year graft survival rates were 94.0% and 86.8%, respectively. One- and 2-year patient survival rates were 97.4% and 91.9%, respectively. Acute tubular necrosis was the only risk factor for worsening of the graft survival (68.2% versus 85.7% for 2-year survival, P = .001) and the patient survival (81.5% versus 94.4% for 2-year survival, P = .06). No significant correlation was seen between patient survival and other variables.

Conclusions. The results of the present study indicate a favorable outcome in short-term period for deceased-donor kidney transplantation in our center.